Foxes.
The Red Fox Vulpes vulpes is assumed to be the major threat to the Warrumbungle Brush-tailed Rock Wallaby. Foxes shelter in small caves and are agile enough to attack unprotected young and juvenile wallabies. The fox population can be reduced and controlled in the short term by fox baiting. The fox baiting needs to be extensive, regular and ongoing as there is constant movement into controlled areas by outside fox populations.

Other Predators
Cats Felis catus are capable of killing young rock-wallabies, but are not known as important predators. They may potentially carry diseases. Cat numbers may increase as fox numbers decrease.
Wild dogs Canis lupis are rare in the Warrumbungles, and are less agile in rocky habitat. However, pig dogs may potentially disrupt colonies as pig chasing is a common activity of hunters in the district.
Wedge-tailed Eagles Aquila audax may be predators and can be observed flying along cliffs where rock-wallabies exist.
Lace Monitors Varanus varius can grow large enough to prey on young rock-wallabies, but have not been documented as predators.

Goats.
Goats Capra hircus compete with rock-wallabies for food and shelter. They both prefer the same rocky habitat. It has been found that as the number of goat pellets increase at certain sites, the number of rock-wallaby scats decrease. Goats are speculated to be the cause of the demise of at least one colony. The DEC attempts to control goat numbers through annual or twice-yearly aerial shooting using a helicopter. The success of this program is yet to be determined.

Other Herbivores
Rabbits Oryctolagus cuniculus (and Hares) may compete for food during dry times. Control of foxes may allow rabbit populations to increase.
Eastern Wallaroos Macropus robustus and Red-neck Wallaby Macropus rufogriseus may compete with rock-wallabies for both food and habitat as they are both capable of living in steep rocky areas. Swamp Wallaby Wallabia bicolor and Eastern Grey Kangaroo Macropus giganteus may compete with rock-wallabies for food at the base of colonies.

Inbreeding
The small, relatively isolated colonies of Warrumbungle rock-wallabies make them vunerable to the problems associated with inbreeding, such as reduced variability and expression of recessive genes.

Human Disturbance
This is considered to be minimal due to the relatively remote situations of the colonies. There may be some disturbance by bushwalkers, pig hunters, goat control helicopters, and monitoring of colonies by conducting pellet surveys.

Drought
During very dry periods rock-wallabies may be forced to forage further from their rocky shelters for food and water. This increases the competition from other macropods and domestic/feral animals; and increases the risk of predation.

Fire
The colony sites have had long periods free from fire. It is not known whether this has advantaged or disadvantaged the rock-wallabies. Fire alters the structure, composition and possibly the suitability of the vegetation. Intense fire has the potential to destroy colonies.